E-Cigarette Propylene Glycol Increases Risk of Acute Myocardial Infarction?

Despite the hurt, thousands and thousands of folks proceed to smoke regardless of the hazards, typically because of the ensuing habit to nicotine. However, along with nicotine, cigarettes include 1000’s of different substances which are related to elevated morbidity and mortality.

In 2003, digital cigarettes appeared, which work by heating a liquid resolution containing nicotine, which turns into an aerosol or vapor that may be inhaled. It was promoted as a “more healthy” various to conventional cigarettes, nonetheless, along with nicotine, the liquid resolution incorporates propylene glycol, which when heated additionally produces substances related to cardiovascular illnesses, corresponding to formaldehyde, acetaldehyde, toluene, benzene, and so on. .

Also learn: Electronic cigarettes: Sales in Brazil are suspended by the Ministry of Justice

Just a few research have already evaluated the potential relationship of digital cigarettes with coronary artery illness, however the outcomes are controversial. Based on this, a evaluate research was carried out on digital cigarettes and the incidence of acute myocardial infarction (AMI).

Study Methods and Populations Involved

The major end result was prognosis of AMI, and included sufferers who used e-cigarettes, those that by no means used them, and people who have been conventional people who smoke. Based on the search in the principle database, research have been chosen for systematic evaluate and meta-analysis.

Inclusion standards have been: observational or intervention research, no less than ten contributors, knowledge on AMI in sufferers utilizing digital cigarettes, nonsmokers, and conventional people who smoke. There was no age restriction or follow-up interval.


After conducting searches, evaluation of exclusion standards and particular person evaluation of research, 4 have been included for qualitative and quantitative evaluation. All have been cross-sectional research carried out within the United States and revealed in 2018 and 2019. Two of them have been thought of to be of good high quality and two of truthful high quality.

The complete quantity of sufferers was 585,306. Of these, 19,435 used digital cigarettes, 1693 used conventional cigarettes and 553,095 have been non-smokers. Ex-smokers weren’t included.

As a preliminary outcome, AMI was present in 7% of digital cigarette customers, 7.7% of conventional people who smoke and 6.5% of non-smokers. E-cigarette customers have been 33% extra more likely to have an AMI than non-smokers, and this opportunity elevated for many who smoked every day and between consecutive days. In the group utilizing conventional cigarettes, the chances of AMI have been larger than within the group utilizing digital cigarettes, p 0.02.

Learn extra: ATS 2022: Pathophysiology of EVALI and e-cigarette use

Comments and Conclusions

This meta-analysis, regardless of the inclusion of few research and which had a cross-sectional attribute, included a big quantity of contributors, which discovered statistical energy for the outcome: the danger of having AMI with the use of digital cigarettes was decrease than with use. of conventional cigarettes, however larger amongst non-smokers. More research, probably longitudinal, are wanted to higher perceive these relationships and ensure these outcomes.

There are at the moment no knowledge out there to suggest the use of digital cigarettes as a kind of smoking cessation, and till their results on the cardiovascular system are higher understood, their use is mostly advisable.

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