Long-term effects of prenatal administration of magnesium sulfate in preterm infants

Articles revealed in Journal of Obstetrics and Gynecology Research In September 2022, by a gaggle of writers right here Faculty of Medicine, Toyama University In Japan, evaluated the connection between prenatal consumption of magnesium sulfate (MgSO4) and neonatal bone mineralization.


The examine was performed at Toyama University Hospital in Japan. Neonates born between January 2013 and March 2019 between 28 weeks and 0 days to 33 weeks and 6 days of gestation and admitted to the intensive care unit (ICU) had been included.

Neonates (n = 163) had been divided into three teams: long-term Mg administration group (≥ 40 days), short-term magnesium administration group (< 40 days), and non-magnesium group. Serum calcium, phosphorus, magnesium, and alkaline phosphatase had been measured weekly till 1 month of age and bone mineral density. (SOS) was measured by quantitative ultrasound (QUS) Within one week and one month after start.

Long-term use of MgSO4 as a pharmacological remedy in tocolysis is routine in some areas of Japan.


In the extended magnesium administration group, at start, serum calcium values ​​had been considerably decrease and serum phosphorus, Mg and alkaline phosphatase values ​​had been considerably larger, in comparison with the non-Mg group.

Although these biochemical variations disappeared by 2 weeks of age, the values SOS The long-term magnesium administration group was considerably decrease than the no-magnesium group, each at one week and one month after start (p = 0.02 and <0.001, respectively).

When utilizing the tenth percentile of values ​​of SOS The cut-off worth for the period of prenatal MgSO4 administration was 67 days, as a definition of poor bone mineralization, one month after start in the non-magnesium group.

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Since MgSO4 administered to the mom is transferred to the fetus by way of the placenta, a number of adversarial effects of magnesium on bone metabolism have been noticed in the neonate. It is understood that magnesium acts antagonistically on calcium (Ca) and, underneath hypermagnesemia, suppresses the manufacturing of parathyroid hormone, which is a vital issue in calcium regulation.

Long-term prenatal administration of MgSO4 impacts bone mineralization in the early neonatal interval, however the clinically acceptable period of administration relies on effects on bone mineralization. why May be various weeks.

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